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Proteins structure is resolved on different levels and terminology was assigned in order to understand the level of protein structure. So, protein structural studies are very important in order to understand their functions. Proteins studies in terms of their structure and functions and with increasing knowledge, it is concluded that the function of a protein is very much related to their structure. Proteins are involved in different roles in the living organisms, from carrying out important cellular functions like metabolic reactions to being an important structural component of animals, human and plant body parts. Rosetta homology modeling and ab initio fragment assembly with Ginzu domain predictionĬombination of ab initio folding and homology methodsĭetection of templates, alignment, modeling incl.Proteins are polymers of amino acids and 20 different amino acids arranged in infinite patterns to form different types of proteins. Proprietary platform, supported on Windows, Linux and Mac excluded ligand volumes), loop modelling, rotamer libraries for sidechain conformations, relaxation using MM forcefields. Template identification, use of multiple templates and accounting for other environments (e.g. Standalone program mainly in Fortran and Perl Satisfaction of contact and distance restraints Standalone program mainly in Fortran and Python Webserver with job manager, automatically updated fold library, genome searching and other facilities Remote template detection, alignment, 3D modeling, multi-templates, ab initio Template detection, alignment, 3D modeling

Wraps external programs into automated workflowīLAST search, T-Coffee alignment, and MODELLER construction Remote homology detection, protein 3D modeling, binding site predictionĪutomated webserver and Downloadable program A unified interface for: Tertiary structure prediction/3D modelling, 3D model quality assessment, Intrinsic disorder prediction, Domain prediction, Prediction of protein-ligand binding residuesĪutomated webserver and some downloadable programs